So Hyun Jung, Byungsoo Kim, Cheonhyoung Park, Jeongseok Kim, Min Woo Ha, Suckchang Hong, and Hyeung-geun Park*
Research Institute of Pharmaceutical Sciences and College of Pharmacy Seoul National University, Seoul, Korea
A synthetic method for accessing chiral α‐alkylthio‐α‐alkylmalonates was successfully established. The enantioselective α‐sulfenylation of α‐alkylmalonates via phase‐transfer catalysis [N‐alkylthiophthalimide, 50% aq. KOH, toluene, −40 °C and N‐2′,3′,4′‐trifluorophenyl‐dihydroquinidium bromide] provided the corresponding α‐alkylthio‐α‐alkylmalonates in high chemical yields (up to 97%) and optical purities (up to 90% ee).
Asian J. Org. Chem. 2019, 8, 1732–1739